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- Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fate
Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fate
Researchers have successfully grown human fetal kidney organoids that can remain viable in lab cultures for months, closely mimicking natural human kidney development. These organoids retain tissue stem cells identified over a decade ago, enabling them to initiate and restart development—a breakthrough not previously achieved. This system also allows scientists to model congenital kidney malformations in vitro, offering new insights into developmental disorders and opening doors for testing the safety of drugs used during pregnancy.
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