IMAJ | volume 16
Journal 2, February 2014
pages: 78-82
Summary
Background: Bisphosphonates reduce the overall risk of fractures among patients with osteoporosis, and this beneficial effect is long-lasting. However, since bisphosphonates inhibit bone remodeling, they may enhance the formation and propagation of micro-cracks over time and patients may therefore be prone to atypical fatigue fractures, mainly in the subtrochanteric region and femoral shaft.
Objectives: To present two cases of subtrochanteric fractures related to bisphosphonate treatment and review of the current literature.
Conclusions: Despite the overall beneficial effect of bisphosphonates, further research is required to prevent this significant complication.