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עמוד בית
Wed, 29.11.23

Original Articles

IMAJ | volume 16

Journal 2, February 2014
pages: 78-82

Atypical Fractures of the Femur Related to Prolonged Treatment with Bisphosphonates for Osteoporosis

    Summary

    Background: Bisphosphonates reduce the overall risk of fractures among patients with osteoporosis, and this beneficial effect is long-lasting. However, since bisphosphonates inhibit bone remodeling, they may enhance the formation and propagation of micro-cracks over time and patients may therefore be prone to atypical fatigue fractures, mainly in the subtrochanteric region and femoral shaft.

    Objectives: To present two cases of subtrochanteric fractures related to bisphosphonate treatment and review of the current literature.

    Conclusions: Despite the overall beneficial effect of bisphosphonates, further research is required to prevent this significant complication. 

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