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עמוד בית
Tue, 23.07.24

Original Articles

IMAJ | volume

Journal 11, November 2003
pages: 775-777

Quick Parathormone Assay in the Surgical Management of Hyperparathyroidism

    Summary

    Background: Among the various new technologies in the field of parathyroid surgery are intraoperative quick parathormone measurements.

    Objectives: To evaluate the contribution of QPTH[1] measurements during parathyroidectomy to the achievement of higher success rates. 

    Methods: QPTH assay using Immulite Turbo Intact PTH[2] was measured in 32 patients undergoing parathyroidectomy: 30 for primary and 2 for secondary hyperparathyroidism.  QPTH levels were measured at time 0 minutes (before incision) and at 10, 20, and 30 minutes after excision of the hyperfunctioning gland.  Only a drop of 60% or more from the 0’ level was considered to be a positive result.

    Results: The mean QPTH level at time 0’ for PHPT[3] patients was 38.12 ± 25.15 pmol/L (range 9.1–118 pmol/L).  At 10 minutes post-excision of the hyperfunctioning gland (or glands), QPTH dropped by a mean of 73.80% to 9.89 ± 18.78 pmol/L. 

    Conclusions: Intraoperative QPTH level measurement is helpful in parathyroid surgery.  A drop of 60% or more from 0’ level indicates a successful procedure, and further exploration should be avoided.



    [1] QPTH = quick parathormone

    [2] PTH = parathormone

    [3] PHPT = primary hyperparathyroidism

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