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עמוד בית
Sat, 15.06.24


IMAJ | volume 25

Journal 9, September 2023
pages: 585-589

Clinical Outcomes of Hospitalized Patients with SARS-CoV-2 Omicron Variant vs. Influenza A During Influenza Season 2021 to 2022: A Retrospective Observational Study

1 Infectious Disease Unit, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel 2 COVID-19 Inpatient Department, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel 3 Internal Medicine Department E, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel 4 Statistics Division, Clinical Research Authority, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel 5 Clinical Microbiology Laboratory, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel 6 Internal Medicine Department C, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel 7 Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel



Influenza and coronavirus disease 2019 (COVID-19) are respiratory diseases with similar modes of transmission. In December 2021, influenza re-emerged after it had been undetected since March 2020 and the Omicron variant replaced the Delta variant. Data directly comparing the two diseases are scarce.


To compare the outcomes of patients with both the Omicron variant and influenza during 2021–2022.


We performed a retrospective study conducted in Beilinson hospital, Israel, from December 2021 to January 2022. We included all hospitalized patients with either laboratory-confirmed COVID-19 or influenza. The primary outcome was 30-day mortality.


We identified 167 patients diagnosed with Omicron and 221 diagnosed with Influenza A. The median age was 71 years for Omicron and 65 years for influenza. Patients with Omicron had a significantly higher Charlson Comorbidity Index score (4 vs. 3, P < 0.001). Patients with Omicron developed more respiratory failure that needed mechanical ventilation (7% vs. 2%, P = 0.05) and vasopressors (14% vs. 2%, P < 0.001) than patients with influenza. In a multivariate model, 30-day mortality was lower in patients diagnosed with influenza than in patients diagnosed with Omicron (19/221 [9%] vs. 44/167 [26%], hazard ratio 0.45, 95% confidence interval 0.25–0.81).


Patients diagnosed with Omicron had higher mortality than patients diagnosed with seasonal influenza. This finding could be due to differences in co-morbidities, the virus pathogenicity, and host responses to infection.

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