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עמוד בית
Wed, 24.07.24

CASE COMMUNICATION

IMAJ | volume 25

Journal 5, May 2023
pages: 381-382

Changes in Electrocardiogram During Romidepsin Therapy: A Case Report

1 Department of Cardiology, Assuta Medical Center, Tel Aviv, Israel 2 Department of Hematology, Assuta Medical Center, Tel Aviv, Israel

Summary

Romidepsin is an intravenously administered antineoplastic agent, which acts by inhibiting histone deacetylases, thus preventing removal of acetyl groups from histones. The accrual of acetyl groups on histones causes cell cycle arrest and apoptotic cell death. It was approved for use in the United States in 2009 for treatment of refractory or relapsed cutaneous and peripheral T cell lymphomas [1-3].

The most common side effects are mild to moderate in severity and include nausea, vomiting, fatigue, fever, myelosuppression (e.g., anemia, neutropenia, thrombocytopenia), elevated liver enzymes, constipation, and rash. More severe adverse events can include marked neutropenia, thrombocytopenia, serious infections such as line sepsis, acute renal failure, tumor lysis syndrome, and cardiac arrhythmias [1].

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2 Twin Towers, 35 Jabotinsky, POB 4292, Ramat Gan 5251108 Israel