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עמוד בית
Thu, 25.07.24

CASE COMMUNICATION

IMAJ | volume 25

Journal 5, May 2023
pages: 369-371

Localized Pulmonary Calcinosis: A Unique Presentation of a Rare Disease

1 Department of Internal Medicine A, Samson Assuta Ashdod University Hospital, Ashdod, Israel 2 Department of Pathology, Samson Assuta Ashdod University Hospital, Ashdod, Israel 3 Department of Radiology, Samson Assuta Ashdod University Hospital, Ashdod, Israel 4 Department of Pulmonology, Samson Assuta Ashdod University Hospital, Ashdod, Israel 5 Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel

Summary

Metastatic pulmonary calcinosis (MPC) is characterized by deposits of calcium in normal pulmonary parenchyma. Diffuse pulmonary calcinosis commonly occurs in hypercalcemia and/or hyperphosphatemia and is more commonly related to renal failure than primary hyperparathyroidism, skeletal metastases, or multiple myeloma [1]. Calcium depositions favor alkaline tissue and are thus more common in the upper lobes of the lung, which have a higher ventilation to perfusion ratio and a low capillary pCO2, resulting in an alkaline pH [2]. Therefore, the most common radiographic manifestation consists of poorly defined nodular opacities bilaterally in the upper lung zones [3].

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