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עמוד בית
Mon, 15.07.24

The Mosaic of Autoimmunity

IMAJ | volume 10

Journal 1, January 2008
pages: 79-82

Chronic Fatigue Syndrome: Characteristics and Possible Causes for its Pathogenesis

    Summary

    Chronic fatigue syndrome is a heterogeneous disorder with unknown pathogenesis and etiology, characterized by disabling fatigue, difficulty in concentration and memory, and concomitant skeletal and muscular pain. Several mechanisms have been suggested to play a role in CFS[1], such as excessive oxidative stress following exertion, immune imbalance characterized by decreased natural killer cell and macrophage activity, immunoglobulin G subclass deficiencies (IgG-1[2], IgG-3) and decreased serum concentrations of complement component. Autoantibodies were also suggested as a possible factor in the pathogenesis of CFS. Recent studies indicate that anti-serotonin, anti-microtubule-associated protein 2 and anti-muscarinic cholinergic receptor 1 may play a role in the pathogenesis of CFS. It has been demonstrated that impairment in vasoactive neuropeptide metabolism may explain the CFS symptoms



    [1] CFS = chronic fatigue syndrome
    [2] IgG = immunoglobulin G

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