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עמוד בית
Thu, 10.07.25

REVIEWS

IMAJ | volume 27

Journal 6, June 2025
pages: 382-387

Unraveling the Microbiome-Psoriasis Connection: Insights into Pathogenesis and Therapeutic Potential

1 Department of Dermatology, Hadassah Medical Center, Jerusalem, Israel 2 Faculty of Medicine, Hebrew University, Jerusalem, Israel

Summary

Psoriasis is a chronic, immune-mediated skin disease characterized by inflammatory lesions and systemic co-morbidities. Emerging evidence highlights the significant role of the microbiome in psoriasis pathogenesis. Dysbiosis of the skin and gut microbiota has been linked to increased disease severity and co-morbidities such as psoriatic arthritis and cardiovascular disease. In this review, we explored the microbiome's influence on immune responses in psoriasis and its potential as a therapeutic target. Microbial therapies, such as probiotics and fecal microbiota transplantation, hold promise for restoring microbial balance and improving outcomes. We also discuss how the microbiome modulates drug efficacy and toxicity, offering insights for personalized treatment approaches. While challenges remain in establishing causality and translating findings into clinical practice, leveraging the gut-skin axis may optimize psoriasis management and improve patient outcomes.

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