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עמוד בית
Fri, 06.12.24

CASE COMMUNICATIONS

IMAJ | volume 26

Journal 7, July - August 2024
pages: 443-446

Idiopathic Eosinophilic Vasculitis: A Case Series

1 Department of Internal Medicine C, Meir Medical Center, Kfar Saba, Israel 2 Department of Rheumatology, Meir Medical Center, Kfar Saba, Israel 3 Department of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel 4 Department of Internal Medicine A, Sheba Medical Center, Tel Hashomer, Israel 5 Department of Clinical Immunology, Angioedema and Allergy, Sheba Medical Center, Tel Hashomer, Israel 6 Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Summary

Idiopathic eosinophilic vasculitis is a newly recognized form of hypereosinophilic syndrome. While little is understood about the condition, criteria for its definition have been proposed. We aimed to determine whether three patients with eosinophilia and vasculitis could be retrospectively diagnosed with this condition. We performed a retrospective descriptive analysis on three cases with hypereosinophilia and vasculitis who were treated in Sheba Medical Center, Sourasky Medical Center, and Meir Medical Center in Israel between 2009 and 2021. A thorough review of all three cases was conducted. The findings were compared to the suggested criteria for idiopathic eosinophilic vasculitis.

All patients shared the symptoms of progressive limb ischemia, eosinophilic rash, and peripheral neuropathy that are consistent with vasculitis. No lower or upper respiratory abnormalities or the presence of anti-neutrophil cytoplasmic antibodies (ANCA) autoantibodies associated with eosinophilic granulomatosis with polyangiitis were detected. Primary monoclonal abnormalities, drug interactions, infections, allergy, and other secondary causes of hypereosinophilia were excluded. After a thorough review, we suggest that our three patients with previously unexplained hypereosinophilia and vasculitis fit the diagnosis of idiopathic eosinophilic vasculitis. These results highlight the existence of this novel condition and the importance of its recognition and consideration as part of the differential diagnosis in patients with marked eosinophilia and vasculitis. Further research for elucidating the mechanisms and treatment approach for this potentially severe condition is urgently needed.

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