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עמוד בית
Fri, 31.03.23


IMAJ | volume 24

Journal 7, July 2022
pages: 448-453

High Prevalence of Acromegaly in Different Industrial Areas: A Population-based Study from Haifa and Western Galilee District in Northern Israel

1Division of Endocrinology and Metabolism, Zvulun Medical Center, Kiryat Bialik, Israel 2Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel 3Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel 4Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel 5Division of Endocrinology and Metabolism, Lin Medical Center, Haifa, Israel 6Rappaport Faculty of Medicine, Technion–Institute of Technology, Haifa, Israel 7Department of Endocrinology and Metabolism, Clalit Health Services, Carmiel, Israel 8Department of Family Medicine, Clalit Health Services, Haifa and Western Galilee District, Israel 9Department of Internal Medicine, Carmel Medical Center, Haifa, Israel



National registries for acromegaly and population-based data make an important contribution to disease understanding and management. Data concerning the epidemiology of acromegaly in Israel is scanty.


To evaluate the epidemiology of acromegaly in different industrial areas in northern Israel.


Data from adult patients diagnosed with acromegaly from 2000 to 2020, living in Haifa and the western Galilee District were collected using the electronic database and medical records from Clalit Health Services. The prevalence of acromegaly in three distinct areas and overall were reported. In addition, other epidemiological data including associated co-morbidities, pituitary tumor size, and treatment modalities were collected.


We identified 77 patients with a confirmed diagnosis of acromegaly. The overall prevalence was 155 cases/106 inhabitants without statistically significant differences between the three areas. The mean age at diagnosis was 50 ± 1.8 years and the male to female ratio was 1.1. Macroadenoma and microadenoma were identified in 44 (57%) and 25 (33%), respectively. The frequency rate of acromegaly-associated co-morbidities such as diabetes, hypertension, carpal tunnel syndrome, and osteoporosis was similar to previously reported studies. The mean body mass index (BMI) was 29 ± 5.6 kg/m2 .Obesity, with a BMI ≥ of 30 kg/m2, was found in 29 patients (38%). The majority of patients underwent transsphenoidal surgery 67 (87%). Normalized insulin-like growth factor 1 was reported in 64 (83%).


A high prevalence of acromegaly was found in northern Israel. The pituitary microadenoma frequency rate is the highest reported.

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