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עמוד בית
Mon, 22.07.24

Special Section: Clinic and Science

IMAJ | volume

Journal 2, February 2001
pages: 114-116

Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion


    Trophic factors such as nerve and fibroblast growth factors are important modulators of 13 cell physiology. These two factors induce the extension of neurite-Iike processes in primary cultures of adult rat 13 cells. Moreover, both NGF and FGF enhance glucose-induced insulin secretion. Since â cells synthesize NGF and pancreatic islet cells produce FGFs, it is possible that autocrine/paracrine interactions may be major regulators of insulin secretion, and impairment of these interactions could lead to pathological states such as diabetes mellitus.

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