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עמוד בית
Sun, 10.11.24

Original Articles

IMAJ | volume

Journal 6, June 2002
pages: 411-414

Effects of Platelet Membrane Glycoprotein Polymorphisms on the Risk of Myocardial Infarction in Young Males

    Summary

    Background: Platelet adhesion and aggregation are mediated by specific platelet membrane glycoproteins GPIa/IIa, GPIba, and GPIIb/IIIa, and are essential steps in thrombus formation and development of acute myocardial infarction.

    Objective: To evaluate the risks exerted by each of the following polymorphisms: HPA-1a/b in GPIIIa; 807C/T in GPIa; and HPA-2a/b, VNTR and Kozak C/T in GPIba in young males with AMI[1]..

    Methods: We conducted a case-control study of 100 young males with first AMI before the age of 53 and 119 healthy controls of similar age. All subjects were tested for the above polymorphisms.

    Results: The allele frequencies of each of the platelet polymorphism were not significantly different between the young men with AMI and the controls. Smoking alone was associated with a 9.97-fold risk, and the presence of at least one metabolic risk factor resulted in a 2.57-fold risk of AMI.

    Conclusion: These results indicate that platelet glycoproteins polymorphisms are not an independent risk factor for AMI.



    [1] AMI = acute myocardial infarction

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