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עמוד בית
Tue, 16.07.24

Original Articles

IMAJ | volume

Journal 3, Mars 2002
pages: 166-169

Novel Insights into the Natural History of Apical Hypertrophic Cardiomyopathy during Long-Term Follow-Up

    Summary

    Background: Long-term follow-up in apical hypertrophic cardiomyopathy is rare.

    Objective: To study the natural history of the disease.

    Methods: We followed 11 patients, 5 women and 6 men, for 5-20 years.

    Results: At presentation all 11 patients had typical features of apical hypertrophic cardiomyopathy, with dyspnea in 3 and chest pains in 8, of whom 5 were typical of angina and 3 had myocardial infarction. R-wave voltage and T-wave negativity progressively decreased in magnitude at serial electrocardiograms in four patients. Perfusion defects were detected on thallium myocardial scintigraphy in three, increased apical uptake in two, and normal in one patient. Apical aneurysm with normal coronary arteries developed in a patient who had sustained ventricular tachycardia. All of the 10 catheterized patients had normal coronaries except for one with significant left anterior descending artery stenosis and another with a minor lesion. Symptomatic sustained ventricular tachycardia was found in two patients, one of whom required the implantation of an internal cardioverter-defibrillator.

    Conclusions: Apical hypertrophic cardiomyopathy may develop morphologic and electrocardiographic changes with life-threatening arrhythmias necessitating close follow-up and treatment.

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