Idit Lachover-Roth MD, Ilan Dalal MD, Avraham Beigelman MD, Alon Hershko MD PhD, Yuval Tal MD PhD, Ramit Maoz Segal MD, Aharon Kessel MD, Arnon Elizur MD
Immunoglobulin E-mediated cow's milk allergy (IgE-CMA) is the most common food allergy in infancy. Recent evidence suggests that early infant feeding practices, particularly the pattern of cow's milk formula (CMF) exposure during the first days and months of life, may influence the risk of developing IgE-CMA. Studies indicate that transient CMF supplementation followed by prolonged avoidance is associated with an increased risk of IgE-CMA, whereas continued regular CMF consumption after initial exposure may reduce this risk. This review summarizes the current evidence regarding IgE-CMA prevention, discusses the limitations of the available data, presents the recommendations of the Israeli Association of Allergy and Clinical Immunology, and highlights key unanswered questions requiring further research.