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עמוד בית
Thu, 25.06.26

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June 2026
Yoram Epstein PhD, Inbal Akavian MD, Amit Assor, Daniel S Moran PhD, Ziv Talmi Yaakov MD, Itay Ketko MSc

Background: Exertional heat stroke (EHS) is common among individuals engaged in high-intensity physical activity. It can lead to long-term organ damage and be a life-threatening condition when diagnosed and treated incorrectly.

Objectives: To track the changes in biomarkers among EHS patients, to suggest a standardized protocol of clinically relevant biomarkers to be followed during hospitalization

Methods: We conducted a retrospective analysis on biomarker changes in seven EHS patients (aged 18–25 years) who were hospitalized for a minimum of 84 hours. Diagnosis of heat stroke was based on extreme body temperature and neurological deficits. Biomarkers indicative of kidney function, liver function, coagulation, muscle breakdown, and systemic inflammation during their hospitalization were analyzed.

Results: The initial average rectal temperature (Tre) was 41.1°C. Patients were cooled to approximately 38.5°C before being transferred to the emergency department (ED). Within the first 24–36 hours of hospitalization, biomarker levels reach peak levels depending on EHS severity. Renal biomarkers rose to 1.5–3 times normal values, while transaminases increased 7–15 times. Creatine phosphokinase, indicating muscle injury, reached an average of 100 times its reference range. Within 24–72 hours. all biomarker levels were normalized.

Conclusions: There is often a gap between the initial temperature of an EHS patient and the temperature recorded at ED admission after cooling. Accurate assessment is context-specific and requires precise biomarker follow-up. Clinical evaluation should continue for at least 48 hours to track organ damage and guide prognosis.

David Erez PhD, Daniel S. Moran PhD, Itay Ketko MSc

Operational forces increasingly face concurrent sleep restrictions and thermal strain, yet mission planning lacks field-relevant guidance on their combined cognitive effects and management. This critical narrative review synthesizes laboratory, field, and military-relevant evidence on how sleep loss and heat stress affect sustained attention, drowsiness, reaction time, executive control, and feedback-guided decision making. Sleep deprivation produces dose-responsive vigilance instability across total sleep deprivation and chronic partial restriction, with lapses and response-time variability providing sensitive monitoring endpoints. Heat stress produces task-dependent cognitive costs. Simple reaction time may remain relatively preserved during modest strain, whereas executive control, working memory, inhibition, and cognitive flexibility appear more vulnerable as physiological reserve narrows, particularly during dehydration, exertion, and protective equipment use.

Military multistressor studies show broad cognitive deterioration when sleep restriction co-occurs with heat, dehydration, undernutrition, and sustained workload. However, bundled designs cannot determine whether sleep and heat act additively, synergistically, or through threshold-dependent interactions. Key gaps include factorial sleep × heat trials, standardized cognitive batteries, mechanistic telemetry, and prospective modeling of moderators such as trait-like sleep-loss vulnerability, baseline sleep debt, chronotype, heat acclimation, hydration practices, protective-equipment burden, and sex. Commanders and medical planners should treat concurrent sleep restriction and thermal strain as a compounded operational risk state and apply layered controls, including protected sleep, scheduling, cooling, hydration, work-rest cycles, objective vigilance screening, task rotation, and supervisory cross-checks for high-consequence decisions.

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