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עמוד בית
Mon, 20.05.24

Original Articles

IMAJ | volume 11

Journal 11, November 2009
pages: 664-668

Chlorhexidine Gluconate 0.02% as Adjunct to Primary Treatment for Corneal Bacterial Ulcers

    Summary

    Background: It is common practice to use topical antiseptic formulations prior to specific therapy in superficial infections and injuries, but not in corneal bacterial ulcers. There is accumulating evidence proving chlorhexidine gluconate 0.02%, an antiseptic agent, as an effective treatment for infectious keratitis.

    Objectives: To investigate the safety and efficacy of chlorhexidine gluconate 0.02% as an adjunct therapy for corneal bacterial ulcers.

    Methods: Twenty-six patients with corneal bacterial ulcers were treated with standard empirical antibiotic treatment. The study group was treated with chlorhexidine gluconate 0.02% while controls received placebo for one week. The patients were followed for at least 1 month.

    Results: No allergic or toxic reactions were noted. Although a higher baseline severity of ulcers existed in the study group, no differences were found in final vision, scarring extent, or recovery duration.

    Conclusions: Chlorhexidine gluconate 0.02% may improve the clinical course of corneal ulcers.

     

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