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עמוד בית
Thu, 05.12.24

The Mosaic of Autoimmunity

IMAJ | volume 10

Journal 1, January 2008
pages: 73-76

Targeting T Regulatory Cells in Autoimmune Diseases

    Summary

    Among the several mechanisms that play a role in maintaining peripheral self-tolerance is the existence of a unique CD4+CD25+ population of naturally occurring regulatory T cells, which actively prevent both the activation and the effector function of autoreactive T cells that have escaped different mechanisms of tolerance. Many studies have shown the benefit of targeting this cell population by restoring self-tolerance. Therapies that could possibly increase the suppressive ability of T regulatory cells were proven to improve the course of autoimmune diseases.

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