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    עמוד בית
    Sat, 12.07.25

    CASE COMMUNICATIONS

    IMAJ | volume 27

    Journal 6, June 2025
    pages: 372-373

    Anifrolumab Induced Bullous Pemphigoid

    1 Department of Dermatology, Emek Medical Center, Afula, Israel 2 Department of Rheumatology, Emek Medical Center, Afula, Israel 3 Rappaport Faculty of Medicine, Technion–Israel Institute of Technology, Haifa, Israel 4 Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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    Summary

    Anifrolumab is a monoclonal antibody approved by the U.S. Food and Drug Administration in 2021 for the treatment of moderate-to-severe systemic lupus erythematosus (SLE) (excluding renal or neurological involvement). The drug inhibits the type 1 interferon receptor. Its safety and efficacy were evaluated through three placebo-controlled studies [1]. Clinical studies have demonstrated the beneficial effects of anifrolumab as an adjunct to standard therapy for SLE with cutaneous manifestations. Common side effects include upper respiratory tract infections, infusion-related reactions, herpes zoster, and hypersensitivity phenomena. Importantly, no serious skin reactions have been previously associated with the use of anifrolumab [2].

    To the best of our knowledge, this is the first reported case of drug-induced bullous pemphigoid (DIBP) following treatment with anifrolumab.

    Full article (PDF)
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