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עמוד בית
Thu, 12.12.24

ORIGINALS

IMAJ | volume 26

Journal 9, October 2024
pages: 560-565

Preliminary Assessment of Galectin-3 Expression in Serum and Follicular Fluid: Implications for Predicting In Vitro Fertilization Outcomes

1 Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel 2 Department of Nephrology and Hypertension, Meir Medical Center, Kfar Saba, Israel 3 Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel

Summary

Background:

Galactin-3 has been found to be involved in oocyte maturation, folliculogenesis, implantation, and placentation. The expression of Galactin-3 in the endometrium of women who have successfully undergone in vitro fertilization (IVF) has been suggested as a potential biomarker for predicting successful embryo implantation.

Objectives:

To evaluate the expression of Galactin-3 in the sera and follicular fluid of women during IVF cycles.

Methods

: This prospective research included 21 women undergoing IVF treatments. Blood samples were taken at four points: day 2 before starting stimulation, trigger day, day of oocyte retrieval, and day of the β-human chorionic gonadotropin level test. In addition, follicular fluid samples were taken on the day of oocyte retrieval. Galactin-3 protein levels were measured in serum and follicular fluid using enzyme-linked immunosorbent assay.

Results:

Galactin-3 levels on the stimulation day were positively correlated to estradiol levels on the day of the trigger (0.59, P = 0.02). Among women who achieved pregnancy compared to those who did not, Galectin-3 serum levels were higher on the day of the trigger (17.93 ± 4.35 ng/ml vs. 11.01 ± 3.73 ng/ml, P = 0.015).

Conclusions:

These findings may imply a potential role of Galectin-3 on the success of IVF treatments, underscoring the potential importance of inflammatory processes in fertility.

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