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עמוד בית
Fri, 13.12.24

ORIGINAL ARTICLES

IMAJ | volume 25

Journal 2, February 2023
pages: 131-136

Omega-3 Intake Improves Clinical Pregnancy Rate in Polycystic Ovary Syndrome Patients: A Double-Blind, Randomized Study

1 Faculty of Life and Health Sciences, Jerusalem College of Technology, Lev Academic Institute, Jerusalem, Israel 2 Department of Bone Marrow Transplantation, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Israel 3 Department of Obstetrics and Gynecology, Bikur Cholim Hospital, Jerusalem, Israel 4 Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Jerusalem, Israel 5 Faculty of Medicine, Hebrew University of Jerusalem, Israel

Summary

Background:

Omega-3 fatty acids promote fertility in males and females and constitute an important factor in the normal development of the fetus.

Objectives:

We investigated the effect of omega-3 supplements during ovulation induction treatment in women with polycystic ovary syndrome (PCOS)-related infertility.

Methods:

A randomized, double-blind study was conducted for 60 treatment cycles in 34 women with PCOS-related oligo/anovulation referred to the fertility clinic at the Bikur Cholim/Shaare Zedek Medical Center in Jerusalem, who underwent ovulation induction with clomiphene citrate (50 mg). Seventeen women (mean age 33.9 ± 0.9 years) received omega-3 supplements (3 × 600 mg/day) and 17 received placebo capsules (mean age 32.7 ± 0.9 years) for a maximum of two cycles. We recorded their characteristics and data from their serial hormonal blood tests and ultrasound examinations. We also conducted both univariate and multivariate analyses. The primary endpoint was conception.

Results:

There were clinical pregnancies in 8/30 (26.7%) treatment cycles for women receiving omega-3 supplements versus 4/30 (13.3%) cycles with placebo. Among overweight/obese women (body mass index [BMI] 25–35), there were clinical pregnancies in 8/27 cycles (29.6%) versus 1/19 (5.3%) with placebo (P < 0.04). For overweight/obese PCOS women, omega-3, lower BMI rates, and higher values of the endometrium’s thickness increased the odds of becoming pregnant. No harmful side effects from the omega-3 treatment were reported.

Conclusions:

Omega-3 supplements demonstrated beneficial effects for fertility in women diagnosed with PCOS. Among the overweight/obese participants, the increased clinical pregnancy rate was significant.

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