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עמוד בית
Fri, 24.05.24

CASE COMMUNICATION

IMAJ | volume 25

Journal 1, January 2023
pages: 72-74

Serum Sickness Reaction Post-MMRV Vaccination in a Pediatric Patient

1 Departments of Pediatrics, Hillel Yaffe Medical Center, Hadera, Israel 2 Departments of Allergy and Immunology, Hillel Yaffe Medical Center, Hadera, Israel

Summary

S

erum sickness is an immune-complex-mediated hypersensitivity reaction that classically presents with fever, rash, polyarthritis, or poly arthralgias. Damage is caused by formation or deposition of antigen-antibody complexes in vessels or tissues. Deposition of immune complexes causes complement activation and/or recruitment of neutrophils by interaction of immune complexes with Fc immunoglobulin G receptors. The condition was first recognized as an entity in the early 1900s in patients who had received heterologous antisera, which was historically used to treat infectious diseases. The symptoms typically occur one to two weeks after exposure to an offending agent and resolve within several weeks of discontinuation [1].

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2 Twin Towers, 35 Jabotinsky, POB 4292, Ramat Gan 5251108 Israel