• IMA sites
  • IMAJ services
  • IMA journals
  • Follow us
  • Alternate Text Alternate Text
עמוד בית
Wed, 12.06.24

Original Articles

IMAJ | volume

Journal 1, January 2000
pages: 22-24

Paroxysmal Nocturnal Hemoglobinuria Associated with in vitro Inhibition of Erythropoiesis by Bone Marrow T Lymphocytes

    Summary

    Background: The etiology of bone marrow failure, a prominent feature of paroxysmal nocturnal hemoglobulinuria, is presently unknown.

    Objectives: To evaluate the possible influence of cellular immune mechanisms in the bone marrow failure of PNH.

    Methods: We studied marrow erythroid colony formation in a patient with paroxysmal nocturnal hemoglobinuria without hypoplastic/aplastic marrow complications.

    Results: In vitro assays revealed a pronounced inhibition of primitive erythroid (BFU-E) progenitor cell growth by marrow T lymphocytes. Removal of T cells prior to culture resulted in a 4.5-fold enhancement of BFU-E numbers. Reevaluation of in vitro erythropoiesis during steroid administration indicated a persistent, albeit less prominent, T cell inhibitory effect.

    Conclusion: Our findings provide the first direct evidence for a cellular immune inhibitory phenomenon accompanying PNH.
    _____________________________
     

    PNH= paroxysmal nocturnal hemoglobinuria

    Legal Disclaimer: The information contained in this website is provided for informational purposes only, and should not be construed as legal or medical advice on any matter.
    The IMA is not responsible for and expressly disclaims liability for damages of any kind arising from the use of or reliance on information contained within the site.
    © All rights to information on this site are reserved and are the property of the Israeli Medical Association. Privacy policy

    2 Twin Towers, 35 Jabotinsky, POB 4292, Ramat Gan 5251108 Israel