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עמוד בית
Sun, 08.12.24

Original Articles

IMAJ | volume

Journal 9, September 2002
pages: 702-705

Asynchronous Replication of Alleles in Genomes Carrying a Microdeletion

    Summary

    Background: While most allelic pairs of DNA replicate synchronously during the S phase of the cell cycle, some genes normally replicate asynchronously, i.e., genes on the X chromosome and imprinted genes. The replication control mechanism is unknown but was shown to be impaired in malignancies and chromosomal trisomies where replication pattern becomes asynchronous.

    Objectives: To determine the level of asynchronization in replication timing of cells from patients with microdeleted genomes.

    Methods: We applied monocolor fluorescent in situ hybridization with different probes on leukocytes from microdeleted genomes.

    Results: All samples derived from the microdeleted genomes showed significantly higher levels of an asynchronized pattern compared to normal individuals.

    Conclusions: Even a “small” genetic imbalance (microdeletion) can interfere with gene replication and cell cycle progression, as previously shown in full trisomies.

     

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