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עמוד בית
Tue, 10.12.24

Original Articles

IMAJ | volume 12

Journal 5, May 2010
pages: 273-276

Characterization and Clinical Outcomes of Drug-Eluting In-Stent Restenosis

    Summary

    Background:

    The best therapeutic alternative for patients suffering from in-stent restenosis after drug-eluting stent implantation remains to be elucidated.

    Objective:

    To characterize the pattern, treatment and outcomes of DES[1]-related in-stent restenosis in patients treated at our institution.

    Methods:

    We determined the incidence and major adverse clinical events in 71 consecutive patients with DES failure among 2473 patients who were treated with 2548 drug-eluting stents between 2004 and 2007. We analyzed the clinical data, procedural parameters and clinical outcomes.

    Results:

    The type and number of stents implanted were as follows:

    Cypher (n=1808), Endeavor (421) and Taxus (319) of these, 53 (2.9%), 10 (2.4%), and 8 (2.5%) patients respectively presented with restenosis. The mean time to restenosis was 11.3 ± 9.9 months. Patients’ mean age was 65 ± 11 years 75% were male, and 68% had diabetes mellitus. Unstable angina was the clinical presentation in 52 (73%). At 6 months, 3 patients had developed myocardial infarction (4.2%), repeat restenosis at follow-up was diagnosed in 8 patients (11.3%), the overall major adverse clinical events rate was 18.3% (13 patients), and 2 patients died (2.8%).

    Conclusions:

    Drug-eluting stent-related restenosis is relatively infrequent but remains a clinical challenge. It occurs more frequently in complex lesion subsets, but the overall intermediate-term prognosis is tolerable.
     

    [1] DES = drug-eluting stent

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