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עמוד בית
Sun, 21.07.24

Original Articles

IMAJ | volume

Journal 6, June 2003
pages: 416-418

The Impact of Congenital Malformations and Mendelian Diseases on Infant Mortality in Israel

    Summary

    Background: Infant mortality in Israel is twofold higher among non-Jews than Jews.

    Objectives: To determine the impact of congenital malformations and Mendelian diseases on infant mortality.

    Methods: We compared the causes of infant mortality in a 4 year period among Jewish and non-Jewish Israeli citizens. Classification was done by analyzing all the death reports according to whether or not the child had any known major malformation, Mendelian disease and/or a syndrome, irrespective of the immediate cause of death.

    Results: The infant mortality among non-Jews was double that among Jews (9 versus 4.4 per 1,000 live births). The rate of children with malformations/genetic syndromes was 3.1 times higher among non-Jews than among Jews (2.94 vs. 1.25 per 1,000 live births). The most significant difference was in the rate of Mendelian diseases, which were 8.3 times more frequent in non-Jewish children (0.16 vs. 1.33 per 1,000 live births respectively). A Mendelian disease was diagnosed in almost 15% of the non-Jewish infants and in less than 5% of the Jewish infants.

    Conclusions: The most striking difference between the Jewish and non-Jewish infants was the incidence of congenital malformations and Mendelian diseases parallel to the differences in the consanguinity rates between the two populations.

     

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