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Objective: To investigate trends in new onset of inflammatory bowel disease (IBD) among Israel Defense Forces (IDF) volunteers exposed to service during the October 7 conflict.
Methods: This retrospective cohort study included 3,477 Israel Defense Forces soldiers who enlisted between 2000 and 2024, had standard medical profiles, developed disqualifying chronic conditions during service, and elected to continue volunteering. Physician-assigned IBD diagnoses were tracked from enlistment through discharge. Hierarchical logistic regression and Cox proportional hazards models assessed the correlation between service during wartime and incident IBD.
Results: Out of 3,477 soldiers, 589 (16.9%) were diagnosed with IBD during service. Multivariable logistic regression revealed that service at wartime (OR = 1.71, 95% CI [1.39–2.10], p < .001), female gender (OR = 1.28, 95% CI [1.07–1.54], p = .009), and higher educational attainment (OR = 3.44, 95% CI [1.07–11.04], p = .038) were independently associated with increased odds of incident IBD. Similarly, in the Cox proportional hazards analysis, wartime service was associated with an earlier IBD diagnosis (HR = 1.65, 95% CI [1.37–1.98], p < .001), indicating a higher rate of onset among those serving during these periods.
Conclusion: Within this selected cohort of IDF volunteers, service during October 7 was associated with higher odds of incident IBD and earlier diagnosis; however, these preliminary results are hypothesis- generating and do not estimate IBD incidence or prevalence among all soldiers. They may relate to the potential role of acute stress and psychosocial factors during military service.