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עמוד בית
Mon, 15.07.24


IMAJ | volume 26

Journal 5, May 2024
pages: 318-323

Gout, Hyperuricemia, and Ear Function: A Systematic Review

1 Rheumatology Unit, Hospital Evangélico Mackenzie, Curitiba, PR, Brazil 2 Department of Internal Medicine and Diagnostic Support, Medical School, Federal University of Bahia, Salvador, Bahia, Brazil


Hearing and vestibular function may be affected by gout and/or hyperuricemia. We performed a systematic review of the literature on ear involvement in patients with gout and hyperuricemia. We selected 24 articles: 8 case reports and 16 original articles. Case reports mainly focused on the presence of tophi in the middle ear, which was resolved with surgical treatment. Seven articles studied the hearing function in relationship to serum uric acid and 10 articles studied the occurrence of vertigo, with one of them studying both aspects. Regarding results on vertigo, five studies showed an association with uric acid elevation, three with lowering of uric acid, and two found no differences. Concerning hearing loss, five studies detected poor hearing function in association with high uric acid levels while other two did not.) Most of the studies showed an association of hearing loss with high uric acid/gout. Regarding vestibular function, the results are too heterogeneous to make any conclusions.

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