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עמוד בית
Mon, 06.12.21


An Approach to the Continuous Dopaminergic Stimulation in Parkinson's Disease

Click on the icon on the upper right hand side for the article by Miguel Schwartz, MD and Sergiu Sabetay, MD.
IMAJ 2012: 14: March: 175-179

Dopaminergic neurons in the basal ganglia normally fire in a continuous manner, maintaining the striatal dopamine concentration at a relatively constant level. In Parkinson’s disease, dopaminergic treatment produces a discontinuous stimulation, inducing an intermittent pulsatile activation of the striatal receptors. Probably the oscillations in the dopamine level in the striatum contribute to the development of motor complications. Treatment with long-acting dopaminergic agents, or providing a more continuous dopaminergic effect in the striatum, has been associated with fewer clinical motor complications. This review describes the state of the art in the clinical approach to achieve the desired continuous dopaminergic stimulation, providing patients with the best clinical effect and probably minimal motor complications.

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