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עמוד בית
Mon, 15.04.24


IMAJ | volume 24

Journal 12, December 2022
pages: 853-854

In-thrombus thrombin secretion: a new diagnostic marker of atrial fibrillation in cryptogenic stroke

1 Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel 2 Institute of Pathology, Sheba Medical Center, Tel Hashomer, Israel 3 Institute of Medical Imaging, Sheba Medical Center, Tel Hashomer, Israel 4 General Hospital, Sheba Medical Center, Tel Hashomer, Israel 5 Neurology, Märkische Kliniken Lüdenscheid, Lüdenscheid, Germany 6 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel


Endovascularly retrieved clots may be a potential resource for diagnosing stroke etiology. This method may influence secondary prevention treatment. We measure thrombin activity eluted by serially washing clots. We concluded that an assay measuring the change in thrombin in clots retrieved during acute stroke endovascular thrombectomy procedures may serve as a diagnostic marker of the origin of the clot. The suggested mechanism for these differences may be the clot location before its retrieval, with high blood flow causing thrombin washout in atherosclerotic clots, in contrast to atrium appendage low blood flow retaining high thrombin levels.

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