Reviews

Novel Biological Treatments for Systemic Lupus Erythematosus: Current and Future Modalities

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Click on the icon on the upper right hand side for the article by Shira Bezalel, MD, Ilan Asher, MD, Daniel Elbirt, MD and Zev Moshe Sthoeger, MD.
IMAJ 2012: 14: August: 508-514
Abstract


Current treatments for systemic lupus erythematosus (SLE) are effective in reducing morbidity and mortality but are not specific and have severe adverse effects. Based on understanding of the different dysregulated immunological pathways involved in SLE pathogenesis, specific targeted therapies were developed. This review presents the current and the near-future novel biological immune targeted treatments, such as B cell-targeted therapy, cytokine blockade, peptide-based treatments and other novel treatments for SLE.